Enliven: Clinical Dermatology

Unusual Presentation and Treatment of Basal Cell Carcinoma with Novel Drug Vismodegib
Author(s): William J. Sanders, BS1, and William E. Freeman, MD

Basal Cell Carcinoma (BCC) is a superficial cancer of the skin that occurs on sun-exposed areas [1,2]. It is more prevalent in those with pale skin, blue eyes, and of Northern European Descent, those older than 60, and more common in men than women [3,4]. It arises from the basal layer of the epidermis. There are many different types of BCC, including nodular, superficial, pigmented, and sclerosing or morpheaform. The most common type, however, is nodular BCC [1]. It presents as a pearly, pink papule with rolled borders that can have some overlying telangiectasia. It can also have some ulceration at the base. These classically occur on the upper lip and nose, particularly on the left side due to exposure while driving a vehicle. It can also present in the older adult who is worried about a new pimple even though they should be too far in age for acne. These lesions are usually caught early enough and are shaved or punched for biopsy. If biopsy shows BCC, the Dermatologic surgeon will perform an exision, Moh’s Micrographic Surgery, or other surgical and non-surgical options. The patient would typically follow-up every 6 months for 2 years [2].