Unusual Presentation and Treatment of Basal Cell Carcinoma with Novel Drug Vismodegib

Copyright: @ 2017 Dr. William J. Sanders. This is an Open Access article published and distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Received Date: 07th February 2017 Accepted Date: 19th May 2017 Published Date: 26th May 2017 Case Report Enliven: Clinical Dermatology ISSN: 2379-5832


Introduction
Basal Cell Carcinoma (BCC) is a superficial cancer of the skin that occurs on sun-exposed areas [1,2]. It is more prevalent in those with pale skin, blue eyes, and of Northern European Descent, those older than 60, and more common in men than women [3,4]. It arises from the basal layer of the epidermis. There are many different types of BCC, including nodular, superficial, pigmented, and sclerosing or morpheaform. The most common type, however, is nodular BCC [1]. It presents as a pearly, pink papule with rolled borders that can have some overlying telangiectasia. It can also have some ulceration at the base. These classically occur on the upper lip and nose, particularly on the left side due to exposure while driving a vehicle. It can also present in the older adult who is worried about a new pimple even though they should be too far in age for acne. These lesions are usually caught early enough and are shaved or punched for biopsy. If biopsy shows BCC, the Dermatologic surgeon will perform an exision, Moh's Micrographic Surgery, or other surgical and non-surgical options.
The patient would typically follow-up every 6 months for 2 years [2]. This is a normal option for those who have insurance and funds to see and pay for dermatologic treatment. However, not everyone has the ability to do this. For the unfortunate who are homeless and or/without job and insurance or money for self-pay, sometimes tumors are neglected. If left alone, the tumor can gradually grow and cause structural, emotional, and socioeconomic problems. This case represents a neglected BCC that grew for many years and became intermittently infected and inflamed so badly that the patient struggled to be hired for any jobs and eventually became homeless.
Essentially his tumor prevented him from providing for himself and thus began a spiral which left him unable to pay for treatment as the tumor grew larger. However, he was given new hope with the novel drug Vismodegib.

Case Presentation
The patient is a 55-year-old white male who presented to the dermatology clinic in dire need of a consultation for a large, nodular, pearly white lesion on the right brow and forehead. The lesion was draining a fowlsmelling discharge which was green in color. He has a past medical history of Basal Cell Carcinoma (BCC) for the past 20 years. He had not been able to obtain treatment for it because he had been mainly homeless. Although he occasionally has worked in construction, he was homeless at presentation. He had previously obtained an MRI and biopsy of the lesion when he had been worked up in various hospitals. The lesion would periodically become infected which caused him to present to the hospital.
The MRI indicated no metastasis, so the patient was given antibiotics and referred to a dermatologist who was my preceptor at the time.
Because he was not able to ever treat the lesion, it had grown tremendously over the past 20 years. Usually, patients with BCC get treatment and the lesion does not grow to be large. However, this patient unfortunately had no financial means with which to get treatment for the cancer. The lesion covered his right brow and forehead region to the point where he had to wear a stocking cap in order to cover it up. This, along with the unavoidable lower level of personal hygiene that accompanies living homeless, caused the patient to have recurrent infections of the ulcerated lesion and a great deal of lowered self-esteem and depression. Figure 1 shows the patient at presentation.
Enliven Archive | www.enlivenarchive.org 2017 | Volume 3 | Issue 1 2 Upon confirmation of the pathology report, the dermatologist who owned the clinic said that this was the largest BCC that has shown up at the clinic.
The pathology report allowed us to try a novel treatment, a drug called Vismodegib. The patient took 150mg by mouth, once daily. Vismodegib has a specific mechanism of action, which will be discussed later. The patient was provided with a manufacturer's discount program setup via the clinic, because he would have otherwise not been able to afford treatment.
After 1 month of oral Vismodegib treatment, the patient presented to the clinic up for a follow-up, and the results were remarkable. The lesion that had previously projected outwardly from his brow and forehead had become drastically smaller. Figure 2 and Figure 3 show the improvement after only 1 month.
With one more month of treatment (a total of 2-months), the cancerous lesion had regressed to the point of being relatively flat again. The patient's overall attitude and self-esteem had improved dramatically. He was now able to wear baseball caps, which made him happy that he did not have to cover the lesion up with a stocking cap during all seasons. Figure 4 and Figure 5 show the patient two months after initiating treatment.For 20 years, this patient was living with a growing cancer on his head, and with a short trial of Vismodegib, the lesion shrunk to a very small size. The next step in the treatment of this patient is to follow up a few months later and then do radiation therapy.
This was an unusually large BCC that had been neglected for far too long.
If financial burden is ever the cause of impediment to the treatment of a patient's condition, effort should be given to alleviate these restrictions. With the help of the manufacturer and in coordination with the dermatologist, this patient was able to obtain an expensive drug which shrunk his cancer by 90%. Let this case report provide clinical evidence that even neglected BCC of any size can be treated with Vismodegib. In recent years, a new drug has come out to combat this molecular process.
Vismodegib inhibits SMO, which prevents the downstream effect of the hedgehog pathway-induced cellular growth. By inhibiting SMO, the hedgehog pathway is halted [6]. Vismodegib has been shown in clinical trials to be effective for local and locally advanced BCC, but it has been shown to be less effective in those who have resistant BCC's [7]. In the case of our patient who had a gradually enlarging tumor for 20 years, the results of taking Vismodegib daily orally for his BCC were remarkable. In More studies will need to be conducted on the long-term benefits of Vismodegib with local, metastatic, and refractory BCC, but this case provided clinical evidence that Vismodegib is an efficacious viable option.