The aim of this study is to investigate the lesion-related specific morphological characteristics of borderline coronary lesion plaques which are responsible for stable angina pectoris. 86 borderline coronary lesion plaques from stable angina pectoris patients were analyzed by using virtual histology-intravascular ultrasound (VH-IVUS). Patients’ characteristics were compared. In the laboratory findings, coronary artery disease distribution and virtual histologyintravascular ultrasound detected thin-cap fibroatheroma (TCFA) and thick-cap fibroatheroma (ThCFA) phenotype groups which were tested. Analysis of the borderline coronary lesion plaques indicate major ratio of fibroatheroma, pathological intimal thickening, and less fibrotic plaque. TCFA and ThCFA accounts for only 25% and 33% of the plaque lesions. Fibrofatty and dense calcium tissues improved in TCFA group (P<0.05), and VH-TCFA III, IV account for 45.9%, 43.3% repressively in subtypes. These findings suggest that for angina pectoris with borderline coronary lesion plaques, TCFA occupied only 1/4 proportion of the plaque lesions and the clinical characteristics were similar to ThCFA patients, which may be responsible for the cardiovascular events.
Author(s): Zhi-Hong Zhao, Hua He, Jun Luo, Wei-jian Jiang, Chan Jin, Jun Chen, Sai-hua Wang, Zhong-ping Ning, Chang-zhu
Zheng, Pei Tian, Dan-jie Lu, and Xin-ming Li