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  Protein Domains Na L1
b
L2
c
Dd
(Å)
ψe
(º)
Ligand/
Comments
PDB Resolution (Å)
1 Human IR L1-CR1-L2 11 6 5 55.7 112 Free state 2HR7_A 2.32
  L1-CR1-L2 11 6 5 49.6 141 2HR7_B
  L1-CR1-L2-(FnIII-1)-(FnIII-2) (achain) 10 6 4 45.8 125 Fab 83-7 heavy and light chains 3LOH_E 3.8
  L1-CR1-L2-(FnIII-1)-(FnIII-2) (a chain) 11 6 5 43.6 125 Fab 83-7 heavy and light chains 2DTG 3.8
  L1-CR1-L2-(FnIII-1) 11 6 5 49.8 162 Insulin A and B chains, Fab 83-14- heavyand light chains 3W14_E 4.4
  L1 - CR1 - L2 - (FnIII-1) 11 6 5 49.5 160 3W14_F
2 Human  L1 -CR1 - L2 11 6 5 51.1 103 Free state 1IGR_A 2.6
IGF-1R
3 Human EGFR L1 -CR1 - L2 - CR2 10 5 5 66.7 135 Cetuximab Fab lightchain and  Fab heavy chain 1YY9 2.61
  L1-CR1-L2-CR2 9 4 5 59.6 111 4KRP_A 2.82
  L1-CR1-L2-CR2 10 5 5 61 111 Cetuximab heavy and light chains,   Nanobody/VHH domain EgA1 4KRO_A 3.05
  L1-CR1-L2-CR2 10 5 5 56.7 112 Adnectin 3QWQ_A 2.75
  L1-CR1-L2-CR2 10 5 5 55.7 93 EGF/ 1NQL 2.8
Inactive (lowpH) complex
  L1-CR1-L2-CR2 10 5 5 32.7 -140 EGF 3NJP_A 3.3
  L1-CR1-L2-CR2 10 5 5 32.7 -139 " 3NJP_B "
  L1-CR1-L2-CR2 10 5 5 32.6 -140 EGF 1IVO_A 3.3
  L1-CR1-L2-CR2 10 5 5 32.7 -139 " 1IVO_B "
  L1-CR1-L2 9 4 5 30.6 -144 TGFa 1MOX_A 2.5
  L1-CR1-L2 9 4 5 29.9 -138 1MOX_B "
4 Human  L1-CR1- L2-CR2 10 5 5 26.7 109 Herceptin Fab heavy and light chains, 1N8Z_C 2.52
Erb-B2
  " L1-CR1- L2-CR2 10 5 5 27.5 104 Fab37 heavy and light chains 3N85_A 3.2
  " L1-CR1- L2-CR2 10 5 5 27.3 103 Pertuzumab Fab heavy and light chains 1S78_A 3.25
  " L1-CR1- L2-CR2 10 5 5 27.5 103 " 1S78_B "
  " L1-CR1- L2-CR2 10 5 5 27.5 104 Immunoglobulin G-binding protein A 3MZW_A 2.9
  " L1-CR1- L2-CR2 10 5 5 27.2 107 Fab heavy and light chains 3BE1_A 2.9
  " L1 -CR1 - L2 10 5 5 26.9 106 Free state 2A91 2.5
5 Rat Erb-B2 L1-CR1-L2-CR2 10 5 5 27.3 105 Free state 1N8Y_C 2.4
6 Drosophila Erb-B2 L1-CR1-L2-CR2 10 5 5 31.6 120 Free state 3I2T_A 2.7
  " L1-CR1-L2-CR2 9 4 5 29.5 -119 Protein spitz  3LTF_A 3.2
  " L1-CR1-L2-CR2 9 4 5 29.7 -126 3LTF_C "
  " L1-CR1-L2-CR2 9 4 5 30 -120 Protein spitz 3LTG_A 3.4
  " L1-CR1-L2-CR2 9 4 5 31.1 -127 3LTG_C "
7 Human  L1-CR1-L2-CR2 10 5 5 69.3 148 Free state 1M6B_A 2.6
Erb-B3
  " L1-CR1-L2-CR2 10 5 5 69.6 148 " 1M6B_B "
  " L1-CR1-L2-CR2 10 5 5 69.1 157 RG7116 Fab heavy and light chains 4LEO_C 2.64
  " L1-CR1-L2-CR2 10 5 5 72.4 150 Fab heavy and light chains 4P59 3.4
  " L1-CR1-L2 10 5 5 69.8 133 Fab DL11 heavy and light chains 3P11_A 3.7
8 Human  L1-CR1-L2-CR2 10 5 5 68.2 112 Free state 2AHX_A 2.4
Erb-B4
  " L1-CR1-L2-CR2 10 5 5 70.1 113 " 2AHX_B "
  " L1-CR1-L2-CR2 9 4 5 68 121 Fab heavy and light chains 3U9U_E 3.42
  " L1-CR1-L2-CR2 9 4 5 67.1 110 " 3U9U_F "
  " L1-CR1-L2 9 4 5 59 125 Free state 3U2P_A 2.57
  " L1-CR1-L2-CR2 10 5 5 32.7 -127 Nrg-1 3U7U_A 3.03
  " L1-CR1-L2-CR2 10 5 5 32.4 -127 " 3U7U_B "
  " L1-CR1-L2-CR2 10 5 5 32.6 -127 " 3U7U_C "
  " L1-CR1-L2-CR2 10 5 5 32.4 -126 " 3U7U_D "
  " L1-CR1-L2-CR2 10 5 5 32.7 -130 " 3U7U_E "
  " L1-CR1-L2-CR2 10 5 5 32.5 -127 " 3U7U_F "

Table 1 Geometric parameters of the structures of the L1 and L2 domains in the IR and EGFR families
a The total repeat number of LRRs determined by the crystal structure.
b The repeat number of LRRs in the L1 domain determined by the crystal structure.
c The repeat number of LRRs in the L2 domain determined by the crystal structure.
d The distance between the L1 and L2 domains
e The angle between the two axes that indicate the direction of parallel stacking of the β-strands in the two L domains.