Objective: To observe the effect of protein concentration of HIC1/SIRT1 on pancreatic cancer model mice.
Method: 30 mice were randomly selected and divided into three groups, each group comprised 10 mice. Cancer cells were injected into model mice. Normal group and model group were given saline. The treatment group was given Buqi-Tongluo-Jiedu decoction. After 14 days, after administering euthanasia the tumor tissues were removed. To detect HIC1/SIRT1 protein concentration, the specimens of each group were examined by WB method.
Result: There is no significant difference between of the treatment group and of the model group in the HIC1 protein concentration, P>0.05. But there is a significant difference compared with that of the normal group, P<0.05. The protein concentration of SIRT1 of the treatment group was significantly lower than the model group, P<0.05, but the protein concentration of SIRT1 of the treatment group was significantly higher than the model group i.e., P<0.05.
Conclusion: Buqi-Tongluo-Jiedu decoction plays a regulatory role on HIC1/SIRT1 protein concentration of the model mice.