Abstract
Background
Control of shivering after anesthesia is essential for optimal perioperative care which can be achieved by various parental medications. The present
study tried to compare the efficacy of intravenous pethidine, ondansetrone and magnesium sulphate in prevention of post anesthetic shivering.
Methodology
150 patients (aged 3-10 years), who were scheduled for day case surgery under general anesthesia, were enrolled in this study. Children were randomly allocated into three groups (50 patients in each) to receive either intravenous pethidine, ondansetrone and magnisum sulphate after induction of anesthesia. The onset, incidence and severity of shivering after recovery of anesthesia were assessed and recorded by a blinded observer in PACU. Also, side effects related to tested drugs were recorded.
Results
Postoperative shivering incidence and severity were comparable between the three studied groups. Shivering onset was delayed in group P when compared to group O and M respectively. The time needed to discharge children from PACU was longer in group P in comparison with both group O and M with no differences between group O and M. Only one child needed overnight stay in group P. Incidence of vomiting and respiratory depression were higher in group P when compared to group O. In group P, the number of over sedated patients were higher when compared to group M.
Conclusion
The prophylactic administration of Ondansetrone and Magnesium sulphate were equally effective as Pethidine in reducing the incidence of post-operative
shivering after anaethesia in pediatric day case surgery. Ondansetrone is considered to be superior to pethidine and magnesium sulphate due to its
potent anti-emetic property.
Author(s): Ahmed M. Farid, MD, Hani I. Taman, MD