Since the proposal of Calvin Bridge and Thomas Hunt Morgan in the spring of 1910 for the so called (non-disjunction) [1], as an origin of Trisomy21 and Down syndrome1, a hot controversy had been raised. Ever after that time up-to-date, no scientific ideas or hypotheses were proposed exactly, to put an end to this long controversy. During my review of literature I found a number of questions and comments have forwarded mainly by Fisch and few others. These questions and comments have summarized the confusion in the researches of this unsolved issue (trisomy 21 and down syndrome). This longstanding (dogma) by scientists about non disjunction trisomy 21 as a maternal cause had arrested a creative thought and losing decades of research (108 years) based on this wrong proposals and interpretation. Previous studies have reported a number of unreliable results, and the direction in studying this issue - (T21 and DS) - was in a wrong path. Nevertheless the false accusation against mother as a leading cause of T21 and down syndrome is continuing till now without any scientific evidence indicating mothers' responsibility.
Author(s): Othman Alfleesy