Author(s): Mariangela Peruzzi, MD, Giuseppe Biondi-Zoccai, MD, Antonino G.M. Marullo, MD, Antonio Barretta, MD, Sara Izzo, Piergiusto Vitulli, and Giacomo Frati MD
Despite the striking improvements recently achieved in the diagnosis and treatment of acute myocardial infarction (AMI), this condition remains a leading cause of death worldwide. The term “ventricular remodeling” refers to changes in ventricular geometry (dilation, sphericity, wall thinning) and stiffness, as well as molecular and functional changes including both cardiomyocytes , other cells of the heart and extracellular matrix.