Background: No studies have been done on the use of Mupirocin 2% cream (MC) in Acne Vulgaris (AV). This is the first report on the use of MC in AV. Objective: To study the effect of MC in AV.
Results: The study was divided into two parts Matched placebo randomized study (MPRS) and Double Blind Study (DBS). 35 patients completed the MPRS study. 30 patients completed the DBS study.
Result: 120 patients having AV have been included in the MPRS study. Of the 120 patients who were included the MPRS study 35 patients came for follow up at week 4 and week 8. 149 patients having AV have been included in the DBS study. Of the 149 patients who were included the DBS study 30 patients have come for follow up at week 8. 41 patients have come for follow up at week 4. Results of MPRS study are of patients who came for follow up at week 4 right side Good 27 (77.1%) left side Good 11 (31.4%) came for follow up at week 8 right side Good 23 (65.7%) left side Good 15 (42.85%). For MPRS Study regarding Grading of Acne at Initial Visit right side Mild 0 left side Mild 4 (11.45%) came for follow up at week 4 right side Mild 8 (22.85%) left side Mild 9 (28.7%) came follow up at week 8 right side Mild 10 (28.55%) left side Mild 11 (31.4%). Results of DBS study are of patients who came for follow up at week 4 Mupirocin 2% cream MC (Active) Good 16 (53.3%) Placebo cream (PC) Good 6 (20%). MC Good 39 (54.9%) PC Good 16 (22.5%). Patients who came for follow up at week 8 MC Good 23 (76.7%) PC Good 12 (40%). For DBS Study regarding Grading of Acne at Initial Visit MC Mild 3 (4.2%) PC Mild 9 (12.7%) came for follow up at week 4 MC Mild 13 (18.3%) PC Mild 14 (19.7%) came for follow up at week 8 MC Mild 9 (30%) PC Mild 7 (23.3%).
Conclusion: MC is of help in AV.