Author(s): Kamel Shibbani and Georges Nemer
GATA4 is a transcription factor that belongs to the GATA family of zinc finger proteins, which are expressed in various organs during mammalian
development including the hematopoietic system, the heart, the gonads, the lungs, and the kidneys. All vertebrate GATA family members have
two zinc finger domains. The C-terminal finger serves as a DNA-binding domain and an interface of interaction with other transcription factors such
as NKX2.5 and TBX5. The N-terminal domain, which is thought to have been acquired by duplication of the C-terminal domain through evolution,
helps in stabilizing the binding to the DNA, and so far has been implicated in the physical interaction with the Friend of GATA (FOG) zinc finger proteins.