Author(s): Charis Whitney, Julie Worthington, Uma Mahesh Gudur and Vinod Nookala
Many antibiotics, especially beta-lactam containing medications, are known to be neurotoxic and can cause symptoms including encephalopathy, aphasia, myoclonus, seizures, and nonconvulsive status epilepticus [1]. Approximately 85% of the drug is excreted by the kidneys, and only a few cases of Cefepime-induced neurotoxicity have been reported in patients with impaired kidney function after dose adjustment [2]. This is a case of Cefepime-induced neurotoxicity that resolved with discontinuation and clearance of this drug by hemodialysis.