Aims/Objective: To analyze soluble thrombotic and inflammatory factors responsible for reperfusion injury followed by PCI in patients of ST elevated Myocardial Infarction (STEMI).
Material and Methods: Ten patients with STEMI who were also thrombolysed and came for routine PCI from 24 hours and after were recruited in the study. Peripheral and coronary sinus blood samples before angioplasty, after balloon dilatation, after stenting and a peripheral blood sample at 24 hours were collected successfully for 6 patients out of 10 recruited. The components analyzed were sCD40L, P-selectin, MCP-1, MMP-9, CKMB and Troponin I.
Results: There was not much variation in the components analysed in the peripheral and coronary blood samples before angioplasty, after balloon dilatation and after stenting. However, in peripheral blood sample at 24 hours significant increase (p<0.05) in soluble (s) CD40L, MCP-1, MMP-9, and sP-Selectin was observed as compared to the peripheral samples before angioplasty.
Conclusion: The present study demonstrated elevated levels at 24 hours of increased soluble inflammatory and thrombotic components following reperfusion by intervention. Modulation of these components may protect the heart from reperfusion injury over and above the conventional management of reperfusion injury for insoluble particulate matter.