Enliven: Clinical Cardiology and Research

References
General Information

Thesis

Correlation between P Wave Dispersion, QRS Duration & QT Dispersion in Hospital Events in Cases of Acute Coronary Syndrome

Mahmoud Fekry Hassan Hassebo, M.B. B.Ch


Visiting Resident, Faculty of Medicine, Department of Critical Care Medicine, Alexandria University


Corresponding author

Mahmoud Fekry Hassan Hassebo, M.B. B.Ch, Visiting Resident, Faculty of Medicine, Department of Critical Care Medicine, Alexandria University, Hospitals University of Alexandria, Egypt, E-mail: mahmoudhassebo@yahoo.com

 

Received Date: 29th October 2015

Accepted Date: 11th February 2016

Published Date: 15th February 2016


Citation

Hassebo MFH (2016) Correlation between P Wave Dispersion, QRS Duration & QT Dispersion in Hospital Events in Cases of Acute Coronary Syndrome. Enliven: Clin Cardiol Res 3(S1): 001.

Copyright

@ 2016 Dr. Mahmoud Fekry Hassan Hassebo. This is an Open Access article published and distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

References

  1. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36: 959-969.

  2. Heidenreich PA, Alloggiamento T, Melsop K, McDonald KM, Go AS, et al. (2001) The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis. J Am Coll Cardiol 38: 478-485.

  3. Scheuermeyer FX, Innes G, Grafstein E, Kiess M, Boychuk B, et al. (2012) Safety and Efficiency of a Chest Pain Diagnostic Algorithm With Selective Outpatient Stress Testing for Emergency Department Patients With Potential Ischemic Chest Pain. Ann Emerg Med 59: 256-264.

  4. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, et al. (2011) ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32: 2999-3054.

  5. Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, et al. (1996) Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 335: 1342-1349.

  6. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, et al. (2007) ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157.

  7. Venge P, Ohberg C, Flodin M, Lindahl B (2010) Early and late outcome prediction of death in the emergency room setting by point-of-care and laboratory assays of cardiac troponin I. Am Heart J 160: 835-841.

  8. Misra D, Leibowitz K, Gowda RM, Shapiro M, Khan IA (2004) Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures: a meta-analysis. Clin Cardiol 27: 607-610.

  9. Charpentier S, Cournot M, Lauque D, Girardi C, Bounes V, et al. (2011) Usefulness of initial glucose level to improve acute coronary syndrome diagnosis in the emergency department. Emerg Med J 28: 564-568.

  10. de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, et al. (2001) The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med 345: 1014-1021.

  11. James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, et al. (2003) N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy. Circulation 108: 275-281.

  12. Cavusoglu E, Marmur JD, Hojjati MR, Chopra V, Butala M, et al. (2011) Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome. Am J Med 124: 724-730.

  13. Katritsis DG, Siontis GC, Kastrati A, van't Hof AW, Neumann FJ, et al. (2011) Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes. Eur Heart J 32: 32-40.

  14. Nabi F, Chang SM, Pratt CM, Paranilam J, Peterson LE, et al. (2010) Coronary artery calcium scoring in the emergency department: identifying which patients with chest pain can be safely discharged home. Ann Emerg Med 56: 220-229.

  15. Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, et al. (2010) Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med 153: 425-434.

  16. Miller CD, Hwang W, Hoekstra JW, Case D, Lefebvre C, et al. (2010) Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med 56: 209-219.

  17. Mehta SR, Yusuf S, Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study Investigators (2000) The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease. Eur Heart J 21: 2033-2041.

  18. Thadani U, Opie LH (1994) Nitrates for unstable angina. Cardiovasc Drugs Ther 8: 719-726.

  19. (1994) Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ 308: 81-106.

  20. Wright RS, Anderson JL, Adams CD, Bridges CR, Casey DE Jr, et al. (2011) 2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients With Unstable Angina/ Non-ST-Elevation Myocardial Infarction (Updating the 2007 Guideline): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 123: 2022-2060.

  21. Squizzato A, Keller T, Romualdi E, Middeldorp S (2011) Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease. Cochrane Database Syst Rev.

  22. Simon T, Steg PG, Gilard M, Blanchard D, Bonello L, et al. (2011) Clinical Events as a Function of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genotype in a Large Nationwide Cohort of Acute Myocardial Infarction: Results From the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Registry. Circulation 123: 474-482.

  23. Morrow DA, Wiviott SD, White HD, Nicolau JC, Bramucci E, et al. (2009) Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: an application of the classification system from the universal definition of myocardial infarction. Circulation 119: 2758-2764.

  24. James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, et al. (2009) Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J 157: 599-605.

  25. Kastrati A, Mehilli J, Neumann FJ, Dotzer F, ten Berg J, et al. (2006) Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA 295: 1531-1538.

  26. Roffi M, Moliterno DJ, Meier B, Powers ER, Grines CL, et al. (2002) Impact of different platelet glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous coronary intervention: : Do Tirofiban and ReoPro Give Similar Efficacy Outcomes Trial (TARGET) 1-year follow-up. Circulation 105: 2730-2736.

  27. Roe MT, Harrington RA, Prosper DM, Pieper KS, Bhatt DL, et al. (2000) Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease.The Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) Trial Investigators. Circulation 102: 1101-1106.

  28. Théroux P, Alexander J Jr, Pharand C, Barr E, Snapinn S, et al. (2000) Glycoprotein IIb/IIIa receptor blockade improves outcomes in diabetic patients presenting with unstable angina/non-ST-elevation myocardial infarction: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) study. Circulation 102: 2466-2472

  29. Oler A, Whooley MA, Oler J, Grady D (1996) Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA 276: 811-815.

  30. FUTURA/OASIS-8 Trial Group, Steg PG, Jolly SS, Mehta SR, Afzal R, et al. (2010) Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. JAMA 304: 1339-1349.

  31. Lev EI, Hasdai D, Scapa E, Tobar A, Assali A, et al. (2004) Administration of eptifibatide to acute coronary syndrome patients receiving enoxaparin or unfractionated heparin: effect on platelet function and thrombus formation. J Am Coll Cardiol 43: 966-971.

  32. van Rees Vellinga TE, Peters RJ, Yusuf S, Afzal R, Chrolavicius S, et al. (2010) Efficacy and safety of fondaparinux in patients with ST-segment elevation myocardial infarction across the age spectrum. Results from the Organization for the Assessment of Strategies for Ischemic Syndromes 6 (OASIS-6) trial. Am Heart J 160: 1049-1055.

  33. Jolly SS, Faxon DP, Fox KA, Afzal R, Boden WE, et al. (2009) Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors or thienopyridines: results from the OASIS 5 (Fifth Organization to Assess Strategies in Ischemic Syndromes) trial. J Am Coll Cardiol 54: 468-476.

  34. Sørensen JT, Terkelsen CJ, Nørgaard BL, Trautner S, Hansen TM, et al. (2011) Urban and rural implementation of pre-hospital diagnosis and direct referral for primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction. Eur Heart J 32: 430-436.

  35. Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, et al. (2006) Bivalirudin for patients with acute coronary syndromes. N Engl J Med 355: 2203-2216.

  36.  Anderson RH, Ho SY, Wharton J, Becker AE (1995) Gross anatomy and microscopy of the conducting system. In: Mandel WJ, ed. Cardiac arrhythmias: their mechanisms, diagnosis, and management. Philadelphia: JB Lippincott 13-54.

  37. Olson CW, Warner RA, Wagner GS, Selvester RH (2001) A dynamic three-dimensional display of ventricular excitation and the generation of the vector and electrocardiogram. J Electrocardiol 34: 7-15.

  38. Macfarlane PW, Lawrie TD, eds. (1989) Comprehensive electrocardiology: theory and practice in health and disease. 1st ed. Vol. 1, ed. PW Macfarlane, TDV Lawrie, 407-57, New York: Pergamon Press.

  39. Surawicz B (1998) Stretching the limits of the electrocardiogram's diagnostic utility. J Am Coll Cardiol 32: 483-485.

  40. Barold SS, Fisch C, Schamroth L, Wellens HJJ (1988) Richard Langendorf: 1908-1987. Pacing Clin Electrophysiol 11: 1242-1247.

  41. Anderson ST, Pahlm O, Selvester RH, Bailey JJ, Berson AS,  et al. (1994) Panoramic display of the orderly sequenced 12-lead ECG. J Electrocardiol 27: 347-352.

  42. Reinig MG, Harizi R, Spodick DH (2005) Electrocardiographic T- and U-wave discordance. Ann Noninvasive Electrocardiol 10: 41-46.

  43. Surawicz B (1998) U wave: facts, hypotheses, misconceptions, and misnomers. J Cardiovasc Electrophysiol 9: 1117-1128.

  44. Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, et al. (1999) The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol 10: 1124-1152.

  45. Viskin S, Rosovski U, Sands AJ, Chen E, Kistler PM, et al. (2005) Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one. Heart Rhythm 2: 569-574.

  46. Bidoggia H, Maciel JP, Capalozza N, Mosca S, Blaksley EJ, et al. (2000) Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am Heart J 140: 678-683.

  47. Sarma JSM, Sarma RJ, Bilitch M, Katz D, Song SL (1984) An exponential formula for heart rate dependence of QT interval during exercise and cardiac pacing in humans: reevaluation of Bazett's formula. Am J Cardiol 54: 103-108.

  48. Kaplan JD, Evans T Jr, Foster E, Lim D, Schiller NB (1994) Evaluation of electrocardiographic criteria for right atrial enlargement by quantitative two-dimensional echocardiography. J Am Coll Cardiol 23: 747-752.

  49. Scott CC, Leier CV, Kilman JW, Vasko JS, Unverferth DV, et al. (1983) The effect of atrial histology and dimension on P wave morphology. J Electrocardiol 16: 363-366.

  50. Alpman A, Galdal M, Berkalp B, Diker E, Erol C, et al. (1995) Importance of notching and slurring of the resting QRS complex in the diagnosis of coronary artery disease. J Electrocardiol 28: 199-208.

  51. Walston A, Brewer DL, Kitchens CS, Krook JE (1974) The electrocardiographic manifestations of spontaneous left pneumothorax. Ann Intern Med 80: 375-379.

  52. Goldberger A (1987) Normal and noninfarct Q waves. Cardiol Clin 5: 357-366.

  53. Bar FW, Brugada P, Dassen WR, van der Werf T, Wellens HJ, et al. (1984) Prognostic value of Q waves, R/S ratio, loss of R wave voltage, ST-T segment abnormalities, electrical axis, low voltage and notching: correlation of electrocardiogram and left ventriculogram. J Am Coll Cardiol 4: 17-27.

  54. Schouten EG, Dekker JM, Meppelink P, Kok FJ, Vandenbroucke JP, et al. (1991) QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 84: 1516-1523.

  55. Bijl M, Verheugt FW (1992) Extreme QT prolongation solely due to reversible myocardial ischemia in single-vessel coronary disease. Am Heart J 123: 524-526.

  56. Barletta G, Lazzeri C, Franchi F, Del Bene R, Michelucci A (2004) Hypertrophic cardiomyopathy: electrical abnormalities detected by the extended-length ECG and their relation to syncope. Int J Cardiol 97: 43-48.

  57. Oka H, Mochio S, Sato K, Isogai Y (1994) Correlation of altered QT interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy. Eur Neurol 34: 23-29.

  58. Hanrahan JP, Choo PW, Carlson W, Greineder D, Faich GA, et al. (1995) Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. Ann Epidemiol 5: 201-209.

  59. Malik M (2004) Errors and misconceptions in ECG measurement used for the detection of drug induced QT interval prolongation. J Electrocardiol 37: 25-33.

  60. Pacher P, Kecskemeti V (2004) Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Curr Pharm Des 10: 2463-2475.

  61. Roden DM (2004) Drugs that prolong the QT interval and/or induce torsade de pointes. N Engl J Med  350: 1013-1022.

  62. Moss AJ, Zareba W, Benhorin J, Locati EH, Hall WJ, et al. (1995) ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation 92: 2929-2934.

  63. Malfatto G, Beria G, Sala S, Bonazzi O, Schwartz PJ (1994) Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic QT syndrome. J Am Coll Cardiol  23: 296-301.

  64. Rosenbaum MB, Acunzo RS (1991) Pseudo 2:1 atrioventricular block and T wave alternans in long QT syndromes. J Am Coll Cardiol 18: 1363-1366.

  65. Zareba W, Moss AJ, le Cessie S, Hall WJ (1994) T wave alternans in idiopathic long QT syndrome. J Am Coll Cardiol 23: 1541-1546.

  66. Schimpf R, Wolpert C, Gaita F, Giustetto C, Borggrefe M (2005) Short QT syndrome. Cardiovasc Res 67: 357-366.

  67. Franz MR, Bargheer K, Costard-JÃckle A, Miller DC, Lichtlen PR (1991) Human ventricular repolarization and T wave genesis. Prog Cardiovasc Dis 33: 369-384.

  68. Alfonso F, Nihoyannopoulos P, Stewart J, Dickie S, Lemery R, et al. (1990) Clinical significance of giant negative T waves in hypertrophic cardiomyopathy. J Am Coll Cardiol 15: 965-971.

  69. Libbus I, Rosenbaum DS (2002) Remodeling of cardiac repolarization: mechanisms and implications of memory. Card Electrophysiol Rev 6: 302-310.

  70. Sgarbossa EB, Meyer PM, Pinski SL, Pavlovic-Surjancev B, Barbagelata A, et al. (2000) Negative T waves shortly after ST-elevation acute myocardial infarction are a powerful marker for improved survival. Am Heart J 140: 385-394.

  71. Tamura A, Nagase K, Mikuriya Y, Nasu M (1999) Significance of spontaneous normalization of negative T waves in infarct-related leads during healing of anterior wall acute myocardial infarction. Am J Cardiol 84: 1341-1344.

  72. Lancellotti P, Gerard PL, Kulbertus HE, Pierard LA (2002) Persistent negative T waves in the infarct-related leads as an independent predictor of poor long-term prognosis after acute myocardial infarction. Am J Cardiol 90: 833-837.

  73. Beckerman J, Yamazaki T, Myers J, Boyle C, Chun S, et al. (2005) T-wave abnormalities are a better predictor of cardiovascular mortality than ST depression on the resting electrocardiogram. Ann Noninvasive Electrocardiol 10: 146-151.

  74. Sclarovsky S (1999) Electrocardiography of acute myocardial ischemic syndromes. London: Martin Dunitz.

  75. Herrick JB (1944) An intimate account of my early experience with coronary thrombosis. Am Heart J 27: 1-18.

  76. Birnbaum Y, Maynard C, Wolfe S, Mager A, Strasberg B, et al. (1999) Terminal QRS distortion on admission is better than ST-segment measurements in predicting final infarct size and assessing the potential effect of thrombolytic therapy in anterior wall acute myocardial infarction. Am J Cardiol 84: 530-534.

  77. Sievers B, John B, Brandts B, Franken U, van Bracht M, et al. (2004) How reliable is electrocardiography in differentiating transmural from non-transmural myocardial infarction? A study with contrast magnetic resonance imaging as gold standard. Int J Cardiol 97: 417-423.

  78. Reimer KA, Ideker RE (1987) Myocardial ischemia and infarction: anatomic and biochemical substrates for ischemic cell death and ventricular arrhythmias. Hum Pathol 18: 462-475.

  79. Essen RV, Merx W, Effert S (1979) Spontaneous course of ST-segment elevation in acute myocardial infarction. Circulation 59: 105-112.

  80. Bren GB, Wasserman AG, Ross AM (1987) The electrocardiogram in patients undergoing thrombolysis for myocardial infarction. Circulation 76: II18-II24.

  81. Justis DL, Hession WT (1992) Accuracy of 22-lead ECG analysis for diagnosis of acute myocardial infarction and coronary artery disease in the emergency department: a comparison with 12-lead ECG. Ann Emerg Med 21: 1-9.

  82. Wilson FN, Johnston FD, Rosenbaum F (1944) The precordial electrocardiogram. Am Heart J 27: 19-85.

  83. Elko PP, Weaver WD, Kudenchuk P, Rowlandson I (1992) The dilemma of sensitivity versus specificity in computer-interpreted acute myocardial infarction. J Electrocardiol 24: 2-7.

  84. Cairns CB, Niemann JT, Selker HP, Laks MM (1992) Computerized version of the time-insensitive predictive instrument. J Electrocardiol 24: 46-49.

  85. O'Rourke MF, Cook A, Carroll G, Gallagher D, Hall J (1992) Accuracy of a portable interpretive ECG machine in diagnosis of acute evolving myocardial infarction. Aust NZ J Med 22: 9-13.

  86. Brady WJ, Perron AD, Martin ML, Beagle C, Aufderheide TP, et al. (2001) Cause of ST segment abnormality in ED chest pain patients. Am J Emerg Med 19: 25-28.

  87. Moon JC, De Arenaza DP, Elkington AG, Taneja AK, John AS, et al. (2004) The pathologic basis of Q-wave and non-Q-wave myocardial infarction: a cardiovascular magnetic resonance study. J Am Coll Cardiol 44: 554-560.

  88. Kaandorp TA, Bax JJ, Lamb HJ, Viergever EP, Boersma E, et al. (2005) Which parameters on magnetic resonance imaging determine Q waves on the electrocardiogram? Am J Cardiol 95: 925-929.

  89. Park SE, Tani A, Minamino T, Azuma J, Kishimoto S, et al. (1990) Coronary angiographic features within 48 hours from onset of non Q wave myocardial infarction with R wave regression and no ST segment depression. Cardiology 77: 121-129.

  90. Barbagelata A, Califf RM, Sgarbossa EB, Goodman SG, Stebbins AL, et al. (1997) Thrombolysis and Q-wave versus non Q-wave first acute myocardial infarction: a GUSTO-I substudy. J Am Coll Cardiol 29: 770-777.

  91. Raitt MH, Maynard C, Wagner GS, Cerqueira MD, Selvester RH, et al. (1995) Appearance of abnormal Q waves early in the course of acute myocardial infarction: implications for efficacy of thrombolytic therapy. J Am Coll Cardiol 25: 1084-1088.

  92. Krucoff MW, Green CE, Satler LF, Miller FC, Pallas RS, et al. (1996) Noninvasive detection of coronary artery patency using continuous ST-segment monitoring. Am J Cardiol 57: 916-921.

  93. Brodie BR, Stuckey TD, Hansen C, VerSteeg DS, Muncy DB, et al. (2005) Relation between electrocardiographic ST-segment resolution and early and late outcomes after primary percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol 95: 343-348.

  94. Zeymer U, Schroder K, Wegscheider K, Senges J, Neuhaus KL, et al. (2005) ST resolution in a single electrocardiographic lead: a simple and accurate predictor of cardiac mortality in patients with fibrinolytic therapy for acute ST-elevation myocardial infarction. Am Heart J 149: 91-97.

  95. De Luca G, Maas AC, van't Hof AW, Ottervanger JP, Hoorntje JC, et al. (2005) Impact of ST-segment depression resolution on mortality after successful mechanical reperfusion in patients with ST-segment elevation acute myocardial infarction. Am J Cardiol 95: 234-236.

  96. Chou TC (1996) Myocardial infarction, myocardial injury, and myocardial ischemia. In: Chou TE, ed. Electrocardiography in clinical practice: adult and pediatric. Philadelphia: WB Saunders 121-213.

  97. Sgarbossa EB, Birnbaum Y, Parrillo JE (2001) ECG diagnosis of acute myocardial infarction: current concepts for the clinician. Am Heart J 141: 507-517.

  98. Richardson K, Engel G, Yamazaki T, Chun S, Froelicher VF, et al. (2005) Electrocardiographic damage scores and cardiovascular mortality. Am Heart J 149: 458-463.

  99. Svensson L, Axelsson C, Nordlander R, Herlitz J (2005) Prehospital identification of acute coronary syndrome/myocardial infarction in relation to ST elevation. Int J Cardiol 98: 237-244.

  100. Hansen DE, Craig CS, Hondeghem LM (1990) Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of electromechanical feedback. Circulation 81: 1094-1105.

  101. Popovic, AD, Neskovic, AN, Pavlovski, K, Marinkovi? J, Babi? R, et al. (1997) Association of ventricular arrhythmias with left ventricular remodelling after myocardial infarction. Heart 77: 423-427.

  102.  Janse MJ, Wit AL (1989) Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischaemia and infarction. Physiol Rev 69: 1049-1169.

  103. Janse MJ, Wit AL (1989) Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischaemia and infarction. Physiol Rev 69: 1049-1169.

  104. Yunus A, Gillis AM, Duff HJ, Wyse DG, Mitchell LB (1996) Increased precordial QTc dispersion predicts ventricular fibrillation during acute myocardial infarction. Am J Cardiol 78: 706-708.

  105. Endoh Y, Kasanuki H, Ohnishi S, Shibata N, Hosoda S, et al. (1997) Influence of early coronary reperfusion on QT interval dispersion after acute myocardial infarction. Pacing Clin Electrophysiol 20: 1646-1653.

  106. Iwasaki T, Suzuki T, Tateno M, Sasaki Y, Oshima S, et al. (1996) Dual-tracer autoradiography with thallium-201 and iodine-125-metaiodobenzylguanidine in experimental myocardial infarction of rat. J Nucl Med 37: 680-684.

  107. Nishimura T, Oka H, Sago M, Matsuo T, Uehara T, et al. (1992) Serial assessment of denervated but viable myocardium following acute myocardial infarction in dogs using iodine-123 metaiodobenzylguanidine and thallium-201 chloride myocardial single photon emission tomography. Eur J Nucl Med 19: 25-29.

  108. Stanton MS, Tuli MM, Radtke NL, Heger JJ, Miles WM, et al. (1989) Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine. J Am Coll Cardiol 14: 1519-1526.

  109.  Inoue H, Zipes DP (1987) Results of sympathetic denervation in the canine heart: Supersensitivity that may be arrhythmogenic. Circulation 75: 877-887.

  110. Hartikainen J, Kuikka J, Mantysaari M, Länsimies E, Pyörälä K (1996) Sympathetic reinnervation after acute myocardial infarction. Am J Cardiol 77: 5-9.

  111. Goldstein JA, Butterfield MC, Ohnishi Y, Shelton TJ, Corr PB, et al. (1994) Arrhythmogenic influence of intracoronary thrombosis during acute myocardial ischemia. Circulation 90: 139-147.

  112. Coronel R, Wilms-Schopman FJG, Janse MJ (1997) Profibrillatory effects of intracoronary thrombus in acute regional ischemia of the in situ porcine heart. Circulation 96: 3985-3991.

  113. McHowat J, Corr PB (1993) Thrombin-induced release of lysophosphatidylcholine from endothelial cells. J Biol Chem 268: 15605-15610.

  114. Clarkson CW, Sawicki G (1981) The effects of lysophosphatidylcholine, a toxic metabolite of ischemia, on the components of cardiac excitability in sheep Purkinje fibers. Circ Res 49: 16-30.

  115. Clarkson CW, Ten Eick RE (1983) On the mechanism of lysophosphatidylcholine-induced depolarization of cat ventricular myocardium. Circ Res 52: 534-556.

  116. Opie LH, Coetzee WA (1988) Role of calcium ions in reperfusion arrhythmias: Relevance to pharmacologic intervention. Cardiovasc Drugs Ther 2: 623-636.

  117. Hagar JM, Kloner RA (1990) Reperfusion arrhythmias: Experimental and clinical aspects. The Age of Reperfusion 2: 1.

  118. Coetzee WA, Opie LH (1987) Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle. Circ Res 61: 157-165.

  119.  (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397-402.

  120. (1988) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 2: 349-360.

  121. (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397-402.

  122. Yoshida Y, Hirai M, Yamada T, Tsuji Y, Kondo T, et al. (2000) Antiarrhythmic efficacy of dipyridamole in treatment of reperfusion arrhythmias: evidence for cAMP-mediated triggered activity as a mechanism responsible for reperfusion arrhythmias. Circulation 101: 624-630.

  123. Rosiak M, Bolinska H, Ruta J (2002) P wave dispersion and P wave duration on SAECG in predicting atrial fibrillation in patients with acute myocardial infarction. Annuals of non invasive electrocardiography  7: 363-368.

  124. Baslaib F, Alkaabi S, Yan AT, Yan RT, Dorian P, et al. (2010) QRS prolongation in patients with acute coronary syndromes. Am Heart J 159: 593-598.

  125. Pekdemir M, Karaca I, Cevik Y, Yanturali S, Ilkay E (2006) The diagnostic value of QT dispersion for acute coronary syndrome in patients presenting with chest pain and nondiagnostic initial electrocardiograms. Mt Sinai J Med 73: 813-817.

  126. Torres M, Moayedi S (2007) Evaluation of the acutely dyspneic elderly patient. Clin Geriatr Med  23: 307-325.

  127. Grech ED, Ramsdale DR (2003) Acute coronary syndrome: unstable angina and non-ST segment elevation myocardial infarction. BMJ 326: 1259-1261.

  128. Achar SA, Kundu S, Norcross WA (2005) Diagnosis of acute coronary syndrome. Am Fam Physician 72: 119-126.

  129. Josephson ME, Kastor JA, Morganroth J (1977) Electrocardiographic left atrial enlargement. Electrophysiologic, echocardiographic and hemodynamic correlates. Am J Cardiol 39: 967-971.

  130. Dilaveris PE, Gialafos EJ, Sideris SK, Theopistou AM, Andrikopoulos GK, et al. (1998) Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation. Am Heart J 135: 733-738.

  131. Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Papanikolaou V, et al. (2000) Clinical and electrocardiographic predictors of recurrent atrial fibrillation. Pacing Clin Electrophysiol 23: 352-358.

  132. Bitzen A, Sternickel K, Lewalter T, Schwab JO, Yang A, et al. (2007) Automatic p wave analysis over 24 hours in patients with paroxysmal or persistent atrial fibrillation. Ann Noninvasive Electrocardiol 12: 306-315.

  133. Cheema AN, Ahmed MW, Kadish AH, Goldberger JJ (1995) Effects of autonomic stimulation and blockade on signal-averaged P-wave duration. J Am Coll Cardiol 26: 497-502.

  134. Nussinovitch U (2012) Meta-Analysis of P-Wave Dispersion Values in Healthy Individuals: The Influence of Clinical Characteristics. Ann Noninvasive Electrocardiol 17: 28-35.

  135. Dilaveris E, Andrikopoulos GK, Metaxas G, Richter DJ, Avgeropoulou CK, et al. (1999) Effects of ischemia on P wave dispersion and maximum P wave duration during spontaneous anginal episodes. Pacing Clin Electrophysiol 22: 1640-1647 .

  136.  Suzuki M, Nishizaki M, Arita M, Ashikaga T, Yamawake N, et al. (1998) Increased QT dispersion in patients with vasospastic angina. Circulation 98: 435-440.

  137. Petrina M, Goodman SG, Eagle KA (2006) The 12-lead electrocardiogram as a predictive tool of mortality after acute myocardial infarction: current status in an era of revascularization and reperfusion. Am Heart J 152: 11-18 .

  138. Brenyo A, Zar?ba W (2011) Prognostic significance of QRS duration and morphology. Cardiol J 18: 8-17.
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